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Availability of data and materials All data generated or analyzed during this study are included in this published article and its supplementary information files (Additional File 2) Abbreviations Ex4: Exendin-4 EPAC2: Exchange Protein Directly Activated by cAMP 2 GLP-1: Glucagon-like peptide 1 GLP-1R: Glucagon-like peptide 1 receptor GPCR: G protein-coupled receptor GRK2: G protein-coupled receptor kinase 2 IR: Insulin resistance PKA: Protein kinase A RRP: Readily releasable pool (of insulin granules) RP: Releasable pool T2D: Type 2 diabetes Adrbk1 : Gene for GRK2 References Rder PV, Wu B, Liu Y, Han W

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