The TGA said since this study it conducted its own independent assessment of the potential association between GLP-1 RAs and NAION and sought advice from the Advisory Committee on Medicines
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Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
The synthesis of thromboxane A2 from arachidonic acid, which serves as a precursor to TBXA2, is facilitated by the activation of phospholipase A2 (PLA2) and subsequent conversion by cyclooxygenase 1 (COX-1) (167)