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In contrast to rodents, IGF-1 levels in humans are usually not reduced with chronic CR unless protein is also restricted 103 (see below)
In conclusion, the experimental data are well described by the model for all knock-downs, except for slight deviations for siKEAP1, where the increase in Keap1-GFP and Srxn1-GFP after DEM exposure was underestimated by the model
Following the experiment, the results reported a reduction in weight and excess fat
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