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Considerations Women of childbearing age treated with this group of drugs should avoid pregnancy and should use a safe method of contraception
This not only destroys the available nitric oxideleading to severe vasoconstriction, poor tissue perfusion, and the symptoms of dysautonomiabut it also damages the eNOS enzyme itself
Both improve glycemic and renal outcomes, but the combination requires careful hydration management
Furthermore, potential crosstalk with other metabolic hormones could be a significant factor
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