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Being trained in GI, nutrition and obesity medicine, I wanted to be able to offer my patients something in addition to lifestyle intervention and I knew this would be impactful. In an earlier case series published in the Journal of Pediatric Gastroenterology and Nutrition , Panganiban and colleagues reported that liraglutide (Saxenda/Victoza, Novo Nordisk), in conjunction with lifestyle intervention, was effective in inducing and maintaining weight loss and improve insulin sensitivity among pediatric patients with metabolic dysfunction-associated steatohepatitis, overweight/obesity and type 2 diabetes

The binding of TNF- to TNFR1 initiates apoptosis via the adaptor protein TRADD, which recruits FADD and subsequently activates caspase-8 to promote the apoptotic cascade (Shakibaei et al., 2005)

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