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Excessive acetyl-CoA production in the process of -oxidation inhibits the tricarboxylic acid (TCA) cycle, leading to mitochondria stress in hepatocytes [9, 10]
477 proteins were found to be differentially expressed (Supplemental Table 1), of which 302 proteins had a minimum fold change of 1.2 (Supplemental Table 2)
The possible role of oxidant/antioxidant imbalance
This approach mirrors strategies used with other peptide therapies to optimize tolerability
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