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NNMT is strongly associated with metabolic regulation, adiposity, glucose balance, and energy expenditure in animal models

A separate 2019 study in older mice reported that NNMT inhibition was associated with how muscle stem cells supported regeneration in rodent models a different research angle from the metabolic work

5-Amino-1MQ reduces NNMT, improving fat function, inflammation, mitochondrial output, and muscle repair.[23][32] In adipocytes, it boosts NAD+ by preventing its wasteful methylation, leading to better glucose handling

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