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In this article, a comprehensive overview of current understanding on the versatile functions of insect GSTs in detoxifying chemical compounds is presented
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Common variants include: GSTM1 null : 40-50% of population-reduced capacity to neutralize environmental toxins GSTP1 variants : Impaired detoxification of carcinogens 6
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
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