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[Abstract]2025 Jan;12(1):e2310308

In this study, we report that a select set of metabolites, such as phosphoenol pyruvate (PEP), glutathione (GSH), 2-hydroxyglutarate (2-HG), and NAD + , display significant differences between the healthy and diseased motor cortex with TDP-43 pathology at a symptomatic stage

Based on this it was observed that the GDH pathway through GDH3, and not GDH1, is necessary for the resistance to stress-induced apoptosis in stationary-phase yeast cells [23]