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During the first few hours after injection, semaglutide concentrations at the injection site are still rising

Bile acids can also stimulate GLP-1.[ref] Importantly, modern exposure to glyphosate and antibiotics may be reducing our natural, constant GLP-1 levels: Animal studies show that GLP-1 levels are reduced due to gut microbiome changes from glyphosate.[ref] Studies using germ-free mice show that GLP-1 secretion after a meal is abolished without the gut microbiome.[ref] How GLP-1 Controls Appetite and Prevents Binge Eating GLP-1 regulates appetite through several distinct mechanisms that affect the brain and the gut

Zhang Y, Lee HW, Lin H et al (2025) Head-to-head comparison between vibration-controlled transient elastography and histology in predicting liver-related events due to metabolic dysfunction-associated steatotic liver disease

This is one reason that mood changes, poor memory and weakness become more common with older age