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Monitoring and Follow-Up Regular monitoring of B12 levels through blood tests is essential to ensure that the treatment is effective and that B12 levels are maintained within the normal range

However, high dose oral vitamin B12 therapy can also be effective, provided that the dose is sufficient, medication adherence is good, and a response is documented

This is why the 3-month cycle framework exists and why a single injection produces minimal results compared to a structured protocol

Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone