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NAC treatment also reduced, in arterial cord blood, citrulline/arginine ratio ( P 0.03, regardless of IPTB severity) and taurine/cysteine ratio ( P 0.04, mainly in moderate IPTB cases), reflecting NO-synthase activity and oxidative cysteine catabolism, respectively (Fig
Q6: Can it be combined with other longevity therapies
To understand the metabolic changes induced by dual inhibition, we comprehensively tested human and murine PDAC cell lines, endogenous tumor models, and patient-derived organoids, which are representative of the full spectrum of PDAC molecular subtypes
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