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If the GLP-1 neurons in the hindbrain are activated by physiological or pharmacological methods, or if the central GLP-1 receptors are activated, Rinaman said, this suppresses motivated behaviors such as food intake, drug self-administration, operant responding for drugs, and exploratory behaviors (Maniscalco and Rinaman, 2018)

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dose reduction of these medications may be needed) [1] Acute kidney injury risk, particularly with severe gastrointestinal adverse reactions causing dehydration Diabetic retinopathy complications , particularly in patients with a history of retinopathy who experience rapid improvement in blood glucose [1] Acute gallbladder disease including cholelithiasis and cholecystitis The FDA label includes a boxed warning about thyroid C-cell tumors observed in rodent studies, though the relevance to humans remains uncertain

Gault VA, Kerr BD, Harriott P, Flatt PR