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Tolerability and Safety Questions Both candidates are likely to be judged partly on gastrointestinal tolerability: nausea, vomiting, diarrhea, constipation, dose escalation, and discontinuation due to adverse events

However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo

But if youre still feeling run down, foggy, or just not quite like yourself, your body may be missing essential nutrients

Although research in humans is still very limited, some studies suggest that vitamin B12 could affect body fat and metabolism