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While the impact of lipid uptake on GSH levels remains unclear, our data strongly argue that an essential role of GSH/GPX4 in activated CD8 + T cells is to sustain their effector function and protect them from ferroptosis as opposed to redox buffering

Electrostatic potentials for ScGrx6 and ScGrx7 were computed and mapped to the protein surface using the PoissonBoltzmann method of Swiss-PDB Viewer (dielectric constant solvent: 80, atomic partial charges, dielectric constant protein: 4, solvent ionic strength: 0.1 M)

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Pregnant women require 1.5 g daily (the same as non-pregnant adults), whilst breastfeeding mothers need 2.0 g to support both their own requirements and those of their infant through breast milk