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All trials were designed to evaluate the primary outcome of MACE defined as cardiovascular death, MI or stroke, with the exception of ELIXA, which included hospitalization for unstable angina as an additional component of their primary outcome

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The essential ones histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine cannot be produced by the body and must be obtained through our diets

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