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Because amylin and GLP-1 signaling act on different receptor systems that both converge on appetite regulation, cagrilintide has been studied extensively in combination with semaglutide (as the investigational combination CagriSema), with published trial data reporting greater weight-reduction outcomes than semaglutide alone

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This strategy is based on an in-depth understanding of the distinct mechanisms of action of the two incretin hormones, GIP and GLP-1, in regulating body weight, glycemic control, and fat storage

Purinergic Signal 2020;16:167174.ArticlePubMedPMC 5