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CrAT deficiency leads to accumulating acetyl-CoA, which exerts an allosteric inhibiting effect on pyruvate dehydrogenase (PDH), a rate-limiting enzyme for pyruvate entry into the Krebs cycle
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2.2 Pharmacokinetics GLPS exhibit low oral bioavailability and are primarily administered intravenously for the treatment of acute liver injury
Injections may also be recommended for those who have had bariatric surgery or other conditions affecting digestion
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