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The most common GLP-1 side effects include: Nausea Diarrhea Vomiting Constipation Stomach pain A study from researchers at Mayo Clinic, presented in 2023, found that half of adults taking semaglutide, the active ingredient in Ozempic and Wegovy, experienced side effects, the most reported ones being nausea (38 percent) and diarrhea (9 percent)

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There are also less common but important risks including gallbladder disease, pancreatitis, dehydration from vomiting or diarrhea, worsening reflux or gastroparesis symptoms

Hormonal fluctuations, particularly the menstrual cycle in women, can cause regular monthly water retention patterns that completely obscure fat loss for one to two weeks per cycle