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A proper skin assessment is more appropriate than assuming that stimulating pigmentation will address the underlying concern
In addition to the genetic information encoded by the primary DNA sequence, epigenetic mechanisms add a layer of regulation of the information and includes DNA methylation, histone modifications as well as regulation by non-coding RNAs (Esteller, 2008
Schneider C.A., Ferrannini E., DeFronzo R., Schernthaner G., Yates J., Erdmann E
Safety, Tolerability & Regulatory Status Safety Profile GHK-Cu demonstrates an excellent safety profile for cosmetic use: Naturally occurring in humans (plasma, saliva, urine) Non-sensitizing in standard patch testing at cosmetic concentrations Long history of topical application in anti-aging and wound care products Minimal reported adverse reactions at appropriate doses Usage Levels and Tolerability Regulatory Status EU : Permitted as a cosmetic ingredient with standard safety assessments US/Asia-Pacific : Allowed under respective cosmetic regulations Formulators must : Perform product-specific safety evaluations, including SDS review, toxicological profiles, and margin of safety calculations Addressing Copper Uglies Literature occasionally references theoretical over-stimulation of MMPs leading to collagen breakdown (sometimes called copper uglies)
