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Together, these renal targeting and biodistribution pathways form the physiological foundation upon which nanoparticle-based interventions for RIRI operate

By increasing selenoprotein synthesis and thereby suppressing CRP production, Se supplementation can compensate for lower levels of Se in serum and liver, and as a result, inflammation will be attenuated [50] Although Se supplementation with sodium selenite decreased CRP levels in acute respiratory distress syndrome (ARDS) patients during the study period, the differences between Se-supplemented and control groups were not significant [51]

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In practice, I see the same pattern