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In particular, when the serum and CSF of PD patients were compared with those of controls, altered levels of sphingolipids (e.g., sphingomyelins and ceramides), phosphatidylcholines, phosphatidylethanolamines and docosahexaenoic acid (DHA) were observed
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The accumulation of misfolded proteins leads to severe ER stress (ERS), which activates the unfolded protein response (UPR) (Oakes and Papa, 2015)
Yue Y, Nabar NR, Shi CS, Kamenyeva O, Xiao X, Hwang IY, et al
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