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The fragment works best when administered in a fasted state, as insulin can blunt its lipolytic activity
In 2009, a double-blind randomised-controlled trial (RCT) found significant reductions in duration of outbreaks, the number of ulcers and the level of pain in those on B12, 1000 g per day sublingually (form not reported), regardless of B12 level
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What has been documented from these sources includes: Headaches, typically described as dull and short-lived Dizziness or light-headedness, particularly after injection Nausea or mild digestive discomfort, more common with oral forms Injection-site reactions including redness, swelling and irritation Appetite changes, sometimes reported as increased hunger Disrupted sleep when dosed in the evening Less commonly, palpitations or mood changes None of these has been formally linked to BPC-157 in peer-reviewed human studies
