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545 For example, pelacarsen, an Lp(a) ASO drug developed by Ionis in collaboration with Novartis AG, effectively lowers Lp(a) levels by selectively cleaving Apo(a) gene (LPA) mRNA
PloS one , 16 (3), e0247307
We were looking at these rodent studies, and were like, these look really promising. And were doing the math on species conversions to figure out human doses. Nobody was under the illusion that what they were doing was definitively safe, he continued
Sin embargo, la evidencia clnica suele ser bastante contradictoria, por lo que no hay resultados concluyentes
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