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Using co-immunoprecipitation (CO-IP), the study confirmed that FOXO4-DRI prevents FOXO4 binding to p53, facilitating phosphorylated p53 nuclear exclusion, which triggers BAX upregulation and cleaved caspase-3 activation driving selective apoptosis of senescent endothelial cells

Effects of recombinant adenovirus hepatocyte growth factor gene on myocardial remodeling in spontaneously hypertensive rats

Hydroxyl radicals generated via Fenton reactions directly increase cerebral edema by impairing ion homeostasis