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Pantothenic acid kinase 2 (PANK2) catalyzes the initial step of phosphorylation of pantothenic acid to 4-phosphopantothenic acid

Nucleic Acids 32 , 302317 (2023)

One possible explanation for such a response is that inhibition of mTORC1 and activation of GCN2 collectively suppresses global translation to conserve nutrients, while selective translation of mRNA such as ATF4 (mediated by increased p-eIF2) activates the expression of AARE genes to mitigate cellular stress

Lilly, for its part, has published ACHIEVE-3 data showing that orforglipron at its highest dose outperformed oral semaglutide 14 mg on both A1C reduction and weight loss in adults with type 2 diabetes, though this comparison involved the Rybelsus-equivalent doses rather than the obesity-approved dose levels