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[11] Notably, clinical studies to date have not identified any severe or lasting adverse events attributable to NAD+ Injection

But inflammation reduction is only part of the story

As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

This page keeps those checks beside the practical product path so readers can distinguish research context from a personal treatment decision