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Clinical data on tirzepatide in type 2 diabetesthe SURPASS clinical trial program Early clinical studies with tirzepatide revealed a marked and dose-dependent reduction of HbA1c and further glycemic parameters in patients with T2D in various ethnic cohorts (clinical trials registration numbers NCT03322631, NCT03131687, and NCT03311724) (6668)

Under stress, there was an observed increase in biochemical markers such as H 2 O 2 , MDA, and electrolyte leakage contents, indicative of ROS occurrence

Current data supports long-term use, but the WHO notes that more research is needed to understand effects beyond 23 years

2025 Sep 4