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Description

When oxidative throughput approaches or exceeds regenerative redox-buffering capacity under constrained substrate inflow, a rate-limiting metabolic state can be conceptualizedreferred to here as a redox bottleneck as discussed in Sect

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The rapid proliferation of tumors requires an increased metabolic rate, which is mainly maintained by mitochondrial respiration, leading to an increased production of reactive oxygen species (ROS) [9]

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