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Clinical data from the SURMOUNT trials showed that approximately 25 to 30 percent of weight lost on tirzepatide comes from lean mass rather than fat

They reduce systemic inflammation , improve adipokine balance, and restore gut barrier function [24] Better pain and physical-function outcomes in osteoarthritis, and reduced flares in patients with rheumatoid arthritis on DMARDs, pointing to dual cardiometabolic and anti-inflammatory benefits.[28][42] Overall, the integration of GLP-1RA into the treatment of autoimmune diseases has yielded partial improvements in disease control and significant benefits in managing metabolic comorbidities. This does not remove the requirement for standard immunotherapies

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You want providers who take a full history, assess your risk, and understand the mechanisms behind what they prescribe