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Patients with established cardiovascular disease showed reductions in major adverse cardiovascular events

What this data doesn't tell us: whether NNMT suppression sustained beyond 12 weeks alters NAD+ metabolism in ways that affect mitochondrial function, whether methylation pathway compensation occurs over longer timescales, or whether adipose tissue remodeling continues linearly or plateaus

Medication Interactions and Contraindications B12 can affect how some medicines work or have risks with certain health conditions