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Eligibility criteria We included RCTs with a duration of intervention of at least 12 weeks that compared tirzepatide at a maintenance dose of 5, 10 or 15 mg once-weekly, administered subcutaneously, with placebo or any other glucose-lowering medication
Individuals at increased risk of selenium deficiency Selenium deficiency has been reported in chronically ill patients who received total parenteral nutrition (TPN) without added selenium for prolonged periods of time
Eating smaller meals and avoiding high-fat or heavily spiced foods during the adjustment period is the most effective prevention strategy
Muscle-liver trafficking of BCAA-derived nitrogen underlies obesity-related glycine depletion
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