The H protein then shuttles this methylamine group to the T protein, which catalyzes the transfer of the methylene group (CH 2 ) to tetrahydrofolate, forming 5,10-methylenetetrahydrofolate
The clinically normal heterozygous carriers for this disease have about half of the normal glutathione synthetase activity, as predicted, but have normal clinical phenotypes, cellular glutathione levels, and 5-oxoproline excretion (53)
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However, oral Glutathione has limited bioavailability, meaning only a portion gets absorbed through digestion