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PE-22-28: PE-22-28 is a synthetic 7-amino acid peptide derived from spadin that selectively blocks TREK-1 two-pore domain potassium channels with an IC50 of 0.12 nM
Mechanistically, it upregulates VEGFR2 signalling, stimulates angiogenesis and fibroblast proliferation, and modulates the inflammatory cytokine response [3]
What is the most likely side effect
It has been used extensively in animal studies, human cell models, and increasingly in off-label therapeutic settings, with minimal toxicity or organ stress reported
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