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23 Age-related oxidative stress affects the nervous, endocrine, and immune systems and may create a vicious cycle involving chronic oxidative stress and inflammation, which support each other, and increase age-related morbidity and mortality
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It is important to note that including patients with a known history of depression and/or anxiety in such studies could bias the results, as these patients are more prone to experience a new episode, which could be wrongfully attributed to GLP-1 RAs drugs
In addition, EA was found to have poor low oral bioavailability, thus limiting its clinical applications
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