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Smith, M.T., Wyse, B.D., Edwards, S.R., El-Tamimy, M., Gaetano, G., Gavin, P., 2015

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[8] According to mathematical modeling, the futile cycle could act as a dampener in the broader network of folate-mediated one-carbon metabolism, stabilizing it against stochastic noise from folate deficiency and/or reduced MTHFR activity due to genetic variation