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Common side effects (usually temporary): Nausea (most frequent, especially after injections) Constipation or loose stools Fatigue and low energy in the first few weeks Reduced appetite (this is also the intended effect) Injection site reactions Less common but serious: Pancreatitis (seek care immediately if you have severe abdominal pain) Gallbladder problems Changes in heart rate Rare thyroid concerns (see contraindications above) Staying well hydrated is important throughout treatment
Cagrilintide and semaglutide work through different mechanisms and have different dosing schedules: Cagrilintide: Amylin receptor agonist Escalation: 0.6 mg 1.2 mg 2.4 mg weekly Three-step titration over 8 weeks Semaglutide: GLP-1 receptor agonist Escalation: 0.25 mg 0.5 mg 1.0 mg 1.7 mg 2.4 mg weekly Five-step titration over 16-20 weeks When combined in CagriSema, both peptides are dosed at 2.4 mg weekly, representing the maximum studied dose for each component
16 Potential side effects of weight loss medications Although there are many FDA-approved weight loss medication options, there are still potential side effects to consider
Semaglutides starting dose begins at a modest .25mg, usually administered as a weekly injection, and gradually escalates to a target dose of 2.4mg after roughly 16 weeks
