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demonstrated that 12 months of resistance training led to significant increases in lumbar spine and whole-body BMD among obese participants, along with improvements in TBS and enhanced femoral neck bone strength, as evidenced by gains in strength index, bending strength index, compression strength index, and impact strength index

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Discontinuation risk appeared higher with orforglipron, including an OR of 4.1 for stopping due to any adverse event and OR of 13.9 for gastrointestinal-related discontinuation

However, ethanol feeding induced CYP2E1 expression in WT mice to levels comparable to those observed in KO mice (Fig