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According to guidance from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), prescription weight management medications are generally intended for adults with obesity or overweight who have weight-related medical problems
The study suggested that these medications could modulate the brain's reward pathways, reducing the reinforcing effects of alcohol and helping to curb cravings (Suchankova et al., 2015)
In this study we employed structure-based site-directed mutagenesis together with pharmacological assays to compare agonist efficacy across two key signaling pathways, cAMP accumulation and ERK1/2 phosphorylation (pERK1/2)
Thats why we modified our protocol
