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After 8 weeks the weekly dosage may be increased to 7.5mg 10mg if necessary
The slow intravenous infusion protocols used in clinical trials minimized these effects, suggesting that rapid bolus administration (which is essentially what subcutaneous injection creates) may increase the likelihood of transient side effects
10.1080/15569527.2022.2050747 159.0 159.1 Ortega-Usobiaga J, Llovet-Osuna F, Djodeyre MR, Bilbao-Calabuig R, Gonzlez-Lpez F, Llovet-Rausell A, Druchkiv V: Outcomes of Laser In Situ Keratomileusis and Photorefractive Keratectomy in Patients Taking Isotretinoin
J Nutr 129:S227S237 Lecker SH, Solomon V, Price SR, Kwon YT, Mitch WE, Goldberg AL (1999) Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats
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