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Food particles, other nutrients, and digestive fluids all create competition at the intestinal wall

For patients without diabetes or clinical ASCVD with an estimated 10-year risk of CVD exceeding 10%, consideration of starting a GLP-1 RA carries a Class 2b, Level of Evidence C recommendation to reduce CV risk

213 A clinical trial in 324 women with overweight and obesity found adhering to a very low-calorie ketogenic diet for 31 days led to improved subjective sleep quality, and sleep improvement was associated with the degree of body fat loss

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