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This process involves various pathogenesis mechanisms, such as pathological calcium signaling in pancreatic acinar cells, changes in pH, coexistence and autophagy, the cleavage of trypsinogen by the lysosomal hydrolytic enzyme tissue protease B to trypsin, and decreased activity of the pancreatic acinar cell trypsin inhibitor (11-13)

Effects of variation in the dietary supply of cysteine and methionine on liver concentration of glutathione and active sulfate (PAPS) and serum levels of sulfate, cystine, methionine and taurine: relation to the metabolism of acetaminophen

doi: 10.1038/s41598-017-00221-9 77 WuWJWolcottRMPruettSB

Oligodendrocyte progenitor cells become regionally diverse and heterogeneous with age