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In summary, the core functional traits of BAs are defined by bifunctional regulation: certain BAs confer cardioprotection through metabolic remodeling (e.g., substrate switching from fatty acids to glucose), anti-inflammatory/antioxidant actions, and structural modulation (e.g., fibrosis inhibition, contractility enhancement)

BMO Capital Markets analysts said in a note to investors that the approval is a much-needed win in light of recent challenges maintaining incretin market share dominance. Having initially led the GLP-1 market, Novo has lost ground amid competition from injectables sold by Eli Lilly and compounding pharmacies

These formulations are not standardized, often lack clinical validation, and may pose safety risks due to inconsistent dosing or quality control

Achar A, Rathi SK