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According to the protective mode, which characterizes the lifestyle of biofilm cells, our analyses revealed the overexpression of enzymes devoted to scavenging diverse ROS: catalase (BC3008), superoxide dismutases ( BC1468, BC4907 ), chloroperoxidase ( BC4774 ), alkylhydroperoxidase ( BC2830 ,), and glyoxalases ( BC5092*, BC3178, BC0824 )

Without basic pharmacokinetic parameters (Cmax, Tmax, AUC, clearance), any dosing recommendation is empirical at best

SILVA, G.S., DE SOUZA, C.W., SILVA, L., MACIEL, G., HUGUENIN, A.B., CARVALHO, M., COSTA, B., SILVA, G., COSTA, C., DIPPOLITO, J.A., COLAFRANCESCHI, A., SCALCO, F

Larger, controlled trials are needed