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Research has used MT-1 in EPP models to characterise the mechanisms through which MC1R activation protects against protoporphyrin-mediated phototoxicity
The increase in cAMP levels in -cells is a consequence of GLP-1R activation in these cells, which in turn enhances the secretion of growth inhibitory hormone through signaling pathways such as PKA and Calcium/Calmodulin-dependent protein kinase (Brereton et al., 2015)
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