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Specifically, GLP-1RAs reduce SREBP-2 expression via activation of the SIRT6-AMPK pathway, resulting in decreased expression of cholesterol and bile acid synthesis genes, and increased expression of genes associated with RCT and LDL-C uptake
Clinical trials show that patients on semaglutide experience improvements in insulin sensitivity markers like HOMA-IR (Homeostasis Model Assessment for Insulin Resistance) within 812 weeks, even before significant weight loss occurs
This can lead to an overgrowth
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