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For example, why do people with diabetes lose less weight than obese, non-diabetics (first Figure from this post expanded to show the difference for the various drugs)

Older individuals produce by a lot less glutathione, which creates increased oxidative stress and cellular damage

Once activated, platelets secrete various immunomodulatory and microbicidal factors stored in their alpha-granules, including defensins, thrombocidins, kinocidins, and other antimicrobial peptides (85)