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The substantial increase in plasma bile acid concentrations (primary, secondary, total and unconjugated bile acid concentrations) with metformin may be explained by the fact that metformin increased the abundance of probiotic bacteria, especially Lactobacillus , and thus their bile salt hydrolase (BSH) gene expression

In doing so, it also reduces appetite and promotes a feeling of fullness, which is why these medications have become central to both diabetes management and weight loss treatment

Retatrutide vs Tirzepatide: Conclusion Choosing between retatrutide vs tirzepatide depends on your unique health needs and goals

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