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Pulsatile GH secretion means GH is released in discrete bursts rather than a steady continuous stream
At the cellular level, the effects of excess soluble urate include perturbation of nitric oxide metabolism [11] and of the renin-angiotensin axis [12], promotion of insulin resistance mediated partly via inhibition of hepatic AMP-activated protein kinase (AMPK) [13], and a role in nonalcoholic steatohepatitis (NASH) through the stimulation of lipogenesis and the inhibition of fatty acid (FA) oxidation [14,15,16,17]
Pande, M
Given these potential mechanisms, it is prudent to consider MB unsafe for the fetus, especially in the mid-trimester period of organ development
