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For example, under combined heat and epigenetic stress, ONSEN (an LTR/Copia retrotransposon in Arabidopsis) generates eccDNA, but only when these stressors are applied together, highlighting the stimulus-specific and context-dependent nature of eccDNA formation (Merkulov et al., 2023)
The secretion of VEGF and IL-6 is crucial in diabetic eye diseases (83)
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